SRC is conveniently situated in the residential area called Block H in Soshanguve, a township in the Tshwane (Pretoria) district of the Gauteng Province in South Africa. Soshanguve is about 35 kilometres north-east of central Pretoria, and has a population of more than 400,000 people and comprises of about 106,000 households.

SRC functions as an independent site. The Centre is easily accessible by public transport, the common mode of transport to the local residents and the wider population. The Centre is stroller and wheelchair friendly and is continually being upgraded for the convenience of clinical trial participants.

The centre has four well-designated clinical areas, namely, an HIV clinic, TB clinic, maternal and paediatric studies clinic and an additional clinic area for other private pharma trials. This set up allows for several trials to be conducted concurrently. All clinic areas comply with relevant health and safety policies. The facilities further include a number of administrative offices, clinical, counselling and interviewing rooms, reception areas, boardrooms, data management facilities, secure filing rooms and an on-site laboratory and pharmacy. The clinical and counselling rooms are suitably equipped to meet clinical trial requirements.

There is an onsite laboratory and pharmacy.

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SRC currently recruits from a wide catchment area, which comprises areas in sub-districts 1 and 2 of the Tshwane district: Soshanguve, Mabopane, Winterveld, Garankuwa, Soutspan, Rosslyn, and Hammanskraal. The catchment area is made up of peri-urban and informal settlements and is densely populated with a total population of close to a million people.